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Acknowledgements The authors would like to thank Lotte Majbrith Badeby, Henning Gustafsson, Berit Bugge Nielsen, Lisette Gammelgaard Nielsen, Betina rtberg Olsen, Lene Von Voss and Pia Von Voss for expert technical assistance

Outcomes vary with dose and consistency and tend to improve when paired with a reduced-calorie diet and more physical activity, so check with your weight loss provider to set safe, realistic goals

Administration Metformin is an oral medication that comes as an immediate-release tablet, extended-release oral tablet, and liquid suspension to be taken by mouth 1-2 times a day with meals

patients should be advised to seek immediate medical attention if these develop

Nutrient Deficiencies: Rapid weight loss can lead to deficiencies in vitamins and minerals that support heart function